Pengaruh Ekstrak Buah Kelapa Sawit (Elaeis Guineensis) Terhadap Kadar Gula Darah, SGOT, SGPT pada Tikus Putih (Rattus Norvegicus) Galur Wistar yang Diinduksi Streptozotocin: Studi in Vivo
Downloads
Hiperglikemia merupakan kondisi kronis yang dapat menyebabkan komplikasi serius, seperti kerusakan organ hati dan peningkatan enzim SGOT serta SGPT, yang berhubungan erat dengan Diabetes Melitus (DM). Salah satu penyebab utama kerusakan jaringan adalah stres oksidatif akibat tingginya kadar glukosa darah. Penanganan DM saat ini mencakup terapi farmakologis, tetapi efek sampingnya mendorong pencarian alternatif berbasis herbal. Buah kelapa sawit (Elaeis guineensis Jacq.), yang kaya akan antioksidan seperti karotenoid dan vitamin E, memiliki potensi antidiabetik dan hepatoprotektif. Mengevaluasi pengaruh ekstrak buah kelapa sawit terhadap kadar glukosa darah, SGOT, dan SGPT pada tikus putih (Rattus norvegicus) galur Wistar yang diinduksi streptozotocin (STZ). Penelitian ini merupakan penelitian eksperimental laboratorik dengan rancangan post-test only with control group, randomized experimental design. Terdapat 5 kelompok yang diberi perlakuan selama 14 hari, yaitu KN (kontrol negatif, pakan standar), KP (kontrol positif, streptozotocin), P1 (streptozotocin + ekstrak buah kelapa sawit 100 mg/kgBB), P2 (streptozotocin + ekstrak 200 mg/kgBB), dan P3 (streptozotocin + ekstrak 300 mg/kgBB). Data dianalisis dengan uji ANOVA dan uji Post Hoc. Uji ANOVA menunjukkan nilai P=0,000 untuk KGD, P=0,013 untuk SGOT, dan P=0,024 untuk SGPT. Uji Post Hoc menunjukkan dosis ekstrak 300 mg/kgBB memberikan hasil P<0,05 dibandingkan dosis 100 dan 200 mg/kgBB. Terdapat pengaruh pemberian ekstrak buah kelapa sawit (Elaeis guineensis) terhadap penurunan nilai KGD, SGOT, dan SGPT pada tikus putih galur Wistar yang diinduksi streptozotocin.
Ajuwon, O. R., Marnewick, J. L., & Davids, L. M. (2022). Red Palm Oil Ameliorates Oxidative Challenge and Inflammatory Responses Associated with Lipopolysaccharide-Induced Hepatic Injury by Modulating NF-?? and Nrf2/GCL/HO-1 Signaling Pathways in Rats. Antioxidants, 11(8), 1629. https://doi.org/10.3390/antiox11081629
Albrahim, T., Alotaibi, M. H., Altamimi, N. M., Albariqi, A. M., & Alqarni, L. A. (2022). The Impact of Dietary Consumption of Palm Oil and Olive Oil on Lipid Profile and Hepatocyte Injury in Hypercholesterolemic Rats. Pharmaceuticals, 15(9), 1103. https://doi.org/10.3390/ph15091103
Ardiani, R., Sari, E., Wahtydi, & Rahmi, S. (2018). Efektivitas Kombinasi Ekstrak Etanol Daun Afrika (Gymnanthemum amygdalinum Del.) dan Kelapa Sawit (Elaeis guineensis Jacq.) terhadap Penurunan Kadar Glukosa Darah pada Tikus. Jurnal Farmasi Dan Herbal, 3(1), 69–74.
Budin, S. B., Othman, F., Louis, S. R., Bakar, M. A., Das, S., & Mohamed, J. (2009). The Effects of Palm Oil Tocotrienol-Rich Fraction Supplementation on Biochemical Parameters, Oxidative Stress and the Vascular Wall of Streptozotocin-Induced Diabetic Rats. Clinics, 64(3), 235–244. https://doi.org/10.1590/S1807-59322009000300011
Federation, I. D. (2021). IDF Diabetes Atlas 10th Edition. International Diabetes Federation. https://www.diabetesatlas.org
Ghorbani, A. (2017). Mechanism of Antidiabetic Effects of Flavonoid Rutin. Biomedicine & Pharmacotherapy, 96, 305–312. https://doi.org/10.1016/j.biopha.2017.10.001
Hosizah, Kuntoro, & HB, N. (2016). Intention and Usage of Computer Based Information Systems in Primary Health Centers. International Journal of Evaluation and Research in Education, 5(2), 113–118. https://doi.org/10.11591/ijere.v5i2.4527
Ichipi-Ifukor, P. C., Asagba, S. O., Nwose, C., Mordi, J. C., & Oyem, J. C. (2022). Palm Oil Extract Protected against Cadmium Chloride Toxicity through Inhibition of Oxidative Stress in Rats. Bulletin of the National Research Centre, 46, 5. https://doi.org/10.1186/s42269-022-00693-6
Mahfoz, A. M., & Gawish, A. Y. (2022). Insight into the Hepatoprotective, Hypolipidemic, and Antidiabetic Impacts of Aliskiren in Streptozotocin-Induced Diabetic Liver Disease in Mice. Diabetology & Metabolic Syndrome, 14, 163. https://doi.org/10.1186/s13098-022-00934-y
Mukherjee, S., & Mitra, A. (2012a). Glucose Metabolism and Energy Production: A Biochemical Overview. Journal of Human Ecology, 26(3), 197–203. https://doi.org/10.1080/09709274.2009.11906182
Mukherjee, S., & Mitra, A. (2012b). Health Effects of Palm Oil. Journal of Human Ecology, 26(3), 197–203. https://doi.org/10.1080/09709274.2009.11906182
Perdani, C. G., Zakaria, F. R., & Pragdimurti, E. (2019). Pemanfaatan Minyak Sawit Mentah sebagai Hepatoprotektor pada Ibu Rumah Tangga di Dramaga Bogor. Jurnal Teknologi Pertanian, 17(2), 119–128. https://doi.org/10.21776/ub.jtp.2019.017.02.4
PERKENI. (2015). Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia. PERKENI.
Prasath, G. S., Pillai, S. I., & Subramanian, S. P. (2019). Fisetin Improves Glucose Homeostasis through Inhibition of Gluconeogenic Enzymes in Liver Tissue of Streptozotocin-Induced Diabetic Rats. European Journal of Pharmacology, 740, 248–254. https://doi.org/10.1016/j.ejphar.2014.07.015
Robergs, R. A., & Griffin, S. E. (2014). Glycerol: Biochemistry, Pharmacokinetics and Clinical and Practical Applications. Sports Medicine, 15(1), 14–31. https://doi.org/10.2165/00007256-199315010-00002
Sinaga, A. G. S. (2018). Potensi Minyak Sawit Merah dan Karotenoid sebagai Suplemen Antioksidan dalam Pengujian Toleransi Glukosa pada Tikus Putih (Preliminary Study). Talenta Conference Series, 1, 251–256. https://doi.org/10.32734/talenta.v1i1.213
Takahashi, H., Tran, P. O., LeRoy, E., Harmon, J. S., Tanaka, Y., & Robertson, R. P. (2004). Glyceraldehyde Causes Production of Intracellular Peroxide in Pancreatic Islets, Oxidative Stress, and Defective ?-Cell Function via Non-Mitochondrial Pathways. Journal of Biological Chemistry, 279, 37423–37429. https://doi.org/10.1074/jbc.M403070200
Takeuti, T. D., Terra, G. A., Silvia, A. A., Juverson, & Terra, A. (2014). Efeito do Óleo de Palma e da Glutamina nos Níveis Séricos de GLP-1, PYY e da Glicemia em Portadores de Diabete Melito Tipo 2 Submetidos à Cirurgia Metabólica. Arquivos Brasileiros de Cirurgia Digestiva, 27(Suppl 1), 51–55. https://doi.org/10.1590/S0102-67202014000500012
Villegas, C. C., Kokuina, E., & Breff, M. C. (2018). Strengthening National Health Priorities for Diabetes Prevention and Management. MEDICC Review, 20(4), 5.
Wang, S. (2019). Fruits with High Antioxidant Activity as Functional Foods BT - Fruits with High Antioxidant Activity as Functional Foods (pp. 371–413). CRC Press.
Zain, M. S., Lee, S. Y., Nasir, N. M., Fakurazi, S., & Shaari, K. (2020). Metabolite Characterization and Correlations with Antioxidant and Wound Healing Properties of Oil Palm (Elaeis guineensis Jacq.) Leaflets via 1H-NMR-Based Metabolomics Approach. Molecules, 25(23), 5636. https://doi.org/10.3390/molecules25235636
Copyright (c) 2026 Muhammad Wal Ikraam Wilyandra, Humairah Medina Liza Lubis
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike 4.0 International (CC-BY-SA). that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
