Correlation Between MMSE Scores and NIHSS In Acute Stroke Infarct Patients
Downloads
Stroke is defined as an episode of neurological dysfunction resulting from focal infarction of the brain, spinal cord, or retina, confirmed by pathological findings, imaging, or other objective evidence of ischemia within a specific vascular territory. Alternatively, stroke may be diagnosed based on the presence of clinical symptoms persisting for ?24 hours or resulting in death, provided other potential causes have been excluded. Stroke patients may experience cognitive, sensory, and motor dysfunction as a result of brain cell damage, which can affect their ability to communicate and carry out daily tasks. Objective: To ascertain the correlation between acute infarction stroke patients' cognitive performance and stroke severity at Dr. Sutomo Surabaya Hospital Methods: An analytical observational cross-sectional design was used in this investigation. Patients diagnosed with acute ischemic stroke who were admitted to Dr. Soetomo Surabaya Hospital between February and May 2023 and who satisfied the inclusion and exclusion criteria made up the study population. A consecutive admission strategy was used for sampling. Serum lactate dehydrogenase (LDH) levels and the National Institutes of Health Stroke Scale (NIHSS) score were evaluated upon admission. Results: The study included 30 patients in all, 14 (46.7%) female and 16 (53.3%) male. There is a correlation between MMSE and NIHSS, according to statistical tests that deem these results significant. The table's results for the correlation test between MMSE and NIHSS Score using the Pearson test show that the p-value is 0.000, where the value is < 0.05. The correlation test's r value is 0.905, meaning that the degree of association between the MMSE score variable and NIHSS is 0.905, or 90.5%, and that the value falls into the strong relationship strength category. The MMSE and NIHSS scores have a negative association; a high or big MMSE score will result in a low NIHSS score, and vice versa. Conclusion: There is a strong negative correlation between MMSE score and functional level assessed by NIHSS in patients with acute ischemic stroke, and statistically significant.
Choi, Y.-A. (2024). Handgrip strength and cognitive recovery in older stroke survivors: A prospective study. Medicina, 60(10), 1697. https://doi.org/10.3390/medicina60101697
Delavaran, H., Jönsson, A. C., Lovkvist, H., et al. (2017). Cognitive function in stroke survivors: A 10-year follow-up study. Acta Neurologica Scandinavica, 136(3), 187–194. https://doi.org/10.1111/ane.12639
El Husseini, N., Katzan, I. L., Rost, N. S., Blake, M. L., Byun, E., Pendlebury, S. T., & Smith, E. E. (2023). Cognitive impairment after ischemic and hemorrhagic stroke: A scientific statement from the American Heart Association/American Stroke Association. Stroke, 54(6), e272–e291. https://doi.org/10.1161/STR.0000000000000430
Jin, T., Li, H., Bao, C., Zhuang, M., Cai, W., Hu, R., … Wu, Y. (2024). Functional near-infrared brain network characteristics analysis in patients with cognitive impairment after stroke. Rehabilitation Medicine, 34(4), 341–348. https://doi.org/10.3724/SP.J.1329.2024.04005
Kementerian Kesehatan Republik Indonesia. (2018). Laporan Nasional RKD 2018 (pp. 1–674). Badan Penelitian dan Pengembangan Kesehatan.
Lees, R., Hendry, B. M., Broomfield, N. M., et al. (2014). Cognitive assessment in stroke: Feasibility and test performance of the Montreal Cognitive Assessment, Mini-Mental State Examination and Addenbrooke’s Cognitive Examination. Clinical Rehabilitation, 28(7), 648–653. https://doi.org/10.1177/0269215513511344
Lyden, P. (2017). Using the National Institutes of Health Stroke Scale. Stroke, 48(2), 513–519. https://doi.org/10.1161/STROKEAHA.116.015434
Makin, S. D. J., Turpin, S., Dennis, M. S., & Wardlaw, J. M. (2018). Cognitive impairment after lacunar stroke: Systematic review and meta-analysis of incidence, prevalence and comparison with other stroke subtypes. Journal of Neurology, Neurosurgery & Psychiatry, 89(5), 535–544. https://doi.org/10.1136/jnnp-2017-317333
Molloy, D. W. (2014). Standardised Mini-Mental State Examination (SMMSE)—Guidelines for administration and scoring instructions. American Journal of Psychiatry, 14, 102–105.
Obaid, M., et al. (2020). Can we prevent poststroke cognitive impairment? An umbrella review of risk factors and treatments. BMJ Open, 10(9), e037982. https://doi.org/10.1136/bmjopen-2020-037982
Pendlebury, S. T., & Rothwell, P. M. (2019). Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: Analysis of the population-based Oxford Vascular Study. The Lancet Neurology, 18(3), 248–258. https://doi.org/10.1016/S1474-4422(18)30442-3
Quinn, T. J., Richard, E., Teuschl, Y., Gattringer, T., Hafdi, M., O’Brien, J. T., & Schmidt, R. (2021). European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment. European Stroke Journal, 6(2), LXXXI–CXXXIII. https://doi.org/10.1177/23969873211042192
Virani, S. S., Alonso, A., Benjamin, E. J., et al. (2020). Heart disease and stroke statistics—2020 update: A report from the American Heart Association. Circulation. https://doi.org/10.1161/CIR.0000000000000757
Wang, Y., Li, Y., Gu, Y., Ma, W., Guan, Y., Guo, M., … Liu, J. (2024). Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment. Neural Regeneration Research, 20(9), 2598–2610. https://doi.org/10.4103/NRR.NRR-D-23-01348
Weaver, N. A., Kuijf, H. J., Aalten, P., et al. (2021). Post-stroke cognitive impairment on the Mini-Mental State Examination primarily relates to left middle cerebral artery infarcts. Stroke, 52(1), 317–320. https://doi.org/10.1161/STROKEAHA.120.032244
Copyright (c) 2025 Lathifatul Fikriyah
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike 4.0 International (CC-BY-SA). that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
